MODELING PRACTICE Immersive Design Methodologies

Modeling Practice is centered around an immersive methodology that connects the architect to the process of making. The value of reflection and a consciousness of methodology are intrinsic layers of thought throughout. The act of building influences the process of design. The experience of creating is as important as the final result. The practice of creating architecture comes with a range of limitations, notably a disconnection from the building process, and in many cases an insubstantial amount of time to interact with the site and surroundings in which the project is located. Throughout many years of working in the profession, the awareness of these particular hindrances to practicing architecture in a fully engaged and fulfilling manner have become prevalent. Prior to the pursuit of an advanced education in architecture, the commencement of a separate, slower endeavor to build a home sparked ideas that lead to the alternative methods of operating that this study investigates. Modeling Practice sets up an immersive methodology that connects the architect to the process of making and building while utilizing a unique studio environment and a site that has been explored, transformed, and reflected upon by the architect over the last seven years. Practice in this manner can be described as unmediated, as there are no time limits of construction, no clients to contend with, and no outside contractors; each decision is made by the architect, and each act of the process is either performed by the architect or directly under the architect’s supervision. The role of the architect is rewritten. The architect investigates, designs, and constructs. The architect is immersed in the site and in the process of creating architecture

Changes in Maximal Strength and Home Run Performance in Ncaa Division I Baseball Players Across 3 Competitive Seasons: A Descriptive Study

The purpose of this longitudinal, descriptive study was to observe changes in maximal strength measured via isometric clean grip mid-thigh pull and home runs (total and home runs per game) across three years of training and three competitive seasons for four National Collegiate Athletic Association (NCAA) Division 1 baseball players. A one-way repeated measures analysis of variance (ANOVA) was performed, revealing significant univariate effects of time for peak force (PF) (p = 0.003) and peak force allometrically scaled (PFa) (p = 0.002). Increases in PF were noted from season 1 to season 2 (p = 0.031) and season 3 (p = 0.004), but season 2 was not significantly different than season 3 (p = 0.232). Additionally, increases in PFa were noted from season 1 to season 2 (p = 0.010) and season 3 (p \u3c 0.001), but season 2 was not significantly different than season 3 (p = 0.052). Home runs per game rose from the 2009 (0.32) to 2010 season (1.35) and dropped during the 2011 season (1.07). A unique aspect of the study involves 2010 being the season in which ball-bat coefficient of restitution (BBCOR) bats were introduced to the NCAA competition

Phase- Specific Changes in Rate of Force Development and Muscle Morphology throughout a Block Periodized Training Cycle in Weightlifters

The purpose of this study was to investigate the kinetic and morphological adaptations that occur during distinct phases of a block periodized training cycle in weightlifters. Athlete monitoring data from nine experienced collegiate weightlifters was used. Isometric mid-thigh pull (IMTP) and ultrasonography (US) results were compared to examine the effects of three specific phases of a training cycle leading up to a competition. During the high volume strength-endurance phase (SE) small depressions in rate of force development (RFD) but statistically significant (p ≤ 0.05) increases in vastus lateralis cross-sectional area (CSA), and body mass (BM) were observed. The lower volume higher intensity strength-power phase (SP) caused RFD to rebound above pre-training cycle values despite statistically significant reductions in CSA. Small to moderate increases only in the earlier RFD time bands (\u3c150 \u3ems) occurred during the peak/taper phase (PT) while CSA and BM were maintained. Changes in IMTP RFD and CSA from US reflected the expected adaptations of block periodized training phases. Changes in early (\u3c100 \u3ems) and late (≥150 ms) RFD time bands may not occur proportionally throughout different training phases. Small increases in RFD and CSA can be expected in well-trained weightlifters throughout a single block periodized training cycle

Assessment of the Effects of Acute and Repeated Exposure to Blast Overpressure in Rodents: Toward a Greater Understanding of Blast and the Potential Ramifications for Injury in Humans Exposed to Blast

Mild traumatic brain injury (mTBI) resulting from exposure to improvised explosive devices (IEDs) has fueled a requirement to develop animals models that mirror this condition using exposure to blast overpressure (BOP). En route to developing a model of repeated exposure to BOP we sought to initially characterize the effects of acute BOP exposure in rodents, focusing specifically on the levels of BOP exposure that produced clinical mTBI symptoms. We first measured BOP effects on gross motor function on a balance beam. Separate groups of unanesthetized rats were exposed (in different orientations) to 36.6, 74.5, and 116.7 kPa BOP exposure inside a pneumatically driven shock tube. Results demonstrated that rats exposed to 116.7 kPa demonstrated transient alterations or loss of consciousness indicated by a transient loss of righting and by increased latencies on the balance beam. The 116.7 kPa exposure was the threshold for overt pathology for acute BOP exposure with approximately 30% of rats presenting with evidence of subdural hemorrhage and cortical contusions. All animals exposed to 116.7 kPa BOP manifested evidence of significant pulmonary hemorrhage. Anterograde memory deficits were observed in rats exposed to 74.5 kPa facing the BOP wave and rats exposed to 116.7 kPa in the lateral (side) orientation. We next assessed repeated exposure to either lateral or frontal 36.6 kPa BOP in anesthetized rats, once per day for 12 days. Results showed that repeated exposure in the frontal, but not side, orientation to the BOP wave produced a transitory learning deficit on a Morris water maze task as shown by significantly longer latencies to reach the submerged platform in the second and third blocks of a four block session. Implications of these data are discussed in relation to the manifestation of mTBI in military personnel exposed to IEDs. Finally, we suggest that there are multiple types of long-term brain injury from blast exposure

Utilizing Weightlifting for Cycling Performance

Abstract available in the 9th Annual Coaches and Sport Science College

Survey of Barbell Trajectory and Kinematics of the Snatch Lift from the 2015 World and 2017 Pan-American Weightlifting Championships

Analysis of elite performances is important to elucidate the characteristics of effective weightlifting technique contributing to the highest level of achievement. The general technique of the weightlifting movements is well established. However, it is also apparent that weightlifting technique can differ based on athlete characteristics. Thus, existing technical models may not accurately reflect current technique of top performers or be applied generically to athletes of different skill, size, sex, or ability. Therefore, the purpose of this descriptive study was to update the scientific knowledge of snatch technique of top international weightlifters. This study used video analysis to determine barbell trajectory and kinematics of 319 successful snatch attempts from two major international competitions. Relative frequencies of barbell trajectory types differed based on competition, sex, category, and ranking. No statistical differences were observed among the top-three performers for either sex for most kinematic variables, and there were no overall discernible patterns of effect size differences for individual or clusters of kinematic variables. The results of this study indicate that weightlifting success can be achieved with a variety of technique profiles

Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine

Objective Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about the enzymatic regulation of heparan sulfate proteoglycans (HSPGs) during the formation and progression of atherosclerotic plaques. Methods and results Swine were rendered diabetic through streptozotocin injection and hyperlipidemic through a high fat diet. Arterial remodeling and local endothelial shear stress (ESS) were assessed using intravascular ultrasound, coronary angiography and computational fluid dynamics at weeks 23 and 30. Coronary arteries were harvested and 142 arterial subsegments were analyzed using histomorphologic staining, immunostaining and real time PCR. Heparanase staining and activity was increased in arterial segments with low ESS, in lesions with thin cap fibroatheroma (TCFA) morphology and in lesions with severely degraded internal elastic laminae. In addition, heparanase staining co-localized with staining for CD45 and MMP-2 within atherosclerotic plaques. Dual staining with gelatinase zymography and heparanase immunohistochemical staining demonstrated co-localization of matrix metalloprotease activity with heparanase staining. A heparanase enzymatic activity assay demonstrated increased activity in TCFA lesions, subsegments with low ESS and in macrophages treated with oxidized LDL or angiotensin II. Conclusions Taken together, our results support a critical role for heparanase in the development of vulnerable plaques and suggest a novel therapeutic target for the treatment of atherosclerosis.Novartis (Firm)Boston Scientific CorporationNational Institutes of Health (U.S.) (Grant R01 GM49039

Performance Comparisons of Youth Weightlifters as a Function of Age Group and Sex

This study was designed to provide an overview of weightlifting performance as a function of age group and sex and evaluate the potential of countermovement jump height (CMJH) as a tool to gauge performance potential. Data from 130 youth athletes (female, n = 65 & male, n = 65) were used to examine progression of performance (Total and Sinclair total) and the relationship between CMJH and Sinclair total while considering interactions between CMJH and age and/or sex. ANOVAs with post hoc analyses revealed that both totals had a statistical first-order polynomial interaction effect between age group and sex and the difference between age groups of 12–13 and 14–15 years old was statistically greater for male than female. A linear model, developed to examine the relationship, revealed that CMJH and CMJH x sex x age rejected the null hypothesis. Our primary findings are that male youth weightlifters have a higher rate of performance progression, possibly owing to puberty, and CMJH may be a better gauging tool for older male youth weightlifters

Natural History of Experimental Coronary Atherosclerosis and Vascular Remodeling in Relation to Endothelial Shear Stress

Author Manuscript: 2011 May 18.Background— The natural history of heterogeneous atherosclerotic plaques and the role of local hemodynamic factors throughout their development are unknown. We performed a serial study to assess the role of endothelial shear stress (ESS) and vascular remodeling in the natural history of coronary atherosclerosis. Methods and Results— Intravascular ultrasound-based 3-dimensional reconstruction of all major coronary arteries (n=15) was performed serially in vivo in 5 swine 4, 11, 16, 23, and 36 weeks after induction of diabetes mellitus and hyperlipidemia. The reconstructed arteries were divided into 3-mm-long segments (n=304). ESS was calculated in all segments at all time points through the use of computational fluid dynamics. Vascular remodeling was assessed at each time point in all segments containing significant plaque, defined as maximal intima-media thickness ≥0.5 mm, at week 36 (n=220). Plaque started to develop at week 11 and progressively advanced toward heterogeneous, multifocal lesions at all subsequent time points. Low ESS promoted the initiation and subsequent progression of plaques. The local remodeling response changed substantially over time and determined future plaque evolution. Excessive expansive remodeling developed in regions of very low ESS, further exacerbated the low ESS, and was associated with the most marked plaque progression. The combined assessment of ESS, remodeling, and plaque severity enabled the early identification of plaques that evolved to high-risk lesions at week 36. Conclusions— The synergistic effect of local ESS and the remodeling response to plaque formation determine the natural history of individual lesions. Combined in vivo assessment of ESS and remodeling may predict the focal formation of high-risk coronary plaque

Comparison of the Relationship between Lying and Standing Ultrasonography Measures of Muscle Morphology with Isometric and Dynamic Force Production Capabilities

The purpose of the current study was (1) to examine the differences between standing and lying measures of vastus lateralis (VL), muscle thickness (MT), pennation angle (PA), and cross-sectional area (CSA) using ultrasonography; and (2) to explore the relationships between lying and standing measures with isometric and dynamic assessments of force production—specifically peak force, rate of force development (RFD), impulse, and one-repetition maximum back squat. Fourteen resistance-trained subjects (age = 26.8 ± 4.0 years, height = 181.4 ± 6.0 cm, body mass = 89.8 ± 10.7 kg, back squat to body mass ratio = 1.84 ± 0.34) agreed to participate. Lying and standing ultrasonography images of the right VL were collected following 48 hours of rest. Isometric squat assessments followed ultrasonography, and were performed on force platforms with data used to determine isometric peak force (IPF), as well as RFD and impulse at various time points. Forty-eight hours later, one-repetition maximum back squats were performed by each subject. Paired-samples t-tests revealed statistically significant differences between standing and lying measurements of MT (p \u3c 0.001), PA (p \u3c 0.001), and CSA (p ≤ 0.05), with standing values larger in all cases. Further, standing measures were correlated more strongly and abundantly to isometric and dynamic performance. These results suggest that if practitioners intend to gain insight into strength-power potential based on ultrasonography measurements, performing the measurement collection with the athlete in a standing posture may be preferred